KPU-300 is a potent and selective antimicrotubule agent. KPU-300 exhibited a potent cytotoxicity with an IC50 of 7.0 nM against HT-29 cells, by strongly binding to tubulin (K d = 1.3 μM) and inducing microtubule depolymerization. References: Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y. Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure. ACS Med Chem Lett. 2014 Jul 23;5(10):1094-8. doi: 10.1021/ml5001883. eCollection 2014 Oct 9. PubMed PMID: 25313318; PubMed Central PMCID: PMC4190642.

纯度：≥98%

CAS：1620692-60-5