Koumine is an indole alkaloid. It reverses thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats in a dose-dependent manner. This effect is mediated by elevated allopregnanolone levels in the spinal cord. References: Qiu HQ, Xu Y, Jin GL, Yang J, Liu M, Li SP, Yu CX. Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain. Mol Pain. 2015 Aug 9;146. doi: 10.1186/s12990-015-0050-1. PubMed PMID: 26255228; PubMed Central PMCID: PMC4529695.

纯度：≥98%

CAS：1358-76-5