重组原癌基因CBL2蛋白

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重组原癌基因CBL2蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

产品名称

重组原癌蛋白CBL2
Recombinant CBL

产品介绍

基因名：

CBL

产品别名：

C-CBL； CBL2； FRA11B； NSLL； RNF55； CBL； Cbl proto-oncogene； Cbl proto-oncogene； E3 ubiquitin-protein ligase CBL； Cas-Br-M (murine) ecotropic retroviral transforming sequence； Cbl proto-oncogene, E3 ubiquitin protein ligase； RING finger protein 55； RING-type E3 ubiquitin transferase CBL； casitas B-lineage lymphoma proto-oncogene； fragile site, folic acid type, rare, fra(11)(q23.3)； oncogene CBL2； proto-oncogene c-Cbl； signal transduction protein CBL；原癌基因CBL2；原癌蛋白CBL2；环指蛋白55(RNF55)；磷酸化原癌基因CBL2；磷酸化原癌蛋白CBL2；

背景信息：

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。