KRX-0601 (UCN-01; KRX0601; 7-hydroxystaurosporine) is a synthetic staurosporine analog with antibiotic and anticancer activity, acting by inhibiting many phosphokinases such as serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases, resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.

纯度：≥98%

CAS：112953-11-4