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重组ATP6V1B2蛋白
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

产品名称
Recombinant ATP6V1B2
Recombinant ATPase H+ transporting V1 subunit B2 protein
产品介绍
基因名:

ATP6V1B2


产品别名:

ATP6B1B2; ATP6B2; DOOD; HO57; VATB; VPP3; Vma2; ZLS2; ATP6V1B2; ATPase H+ transporting V1 subunit B2; ATPase H+ transporting V1 subunit B2; V-type proton ATPase subunit B, brain isoform; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; H+ transporting two-sector ATPase; V-ATPase B2 subunit; V-ATPase subunit B 2; endomembrane proton pump 58 kDa subunit; testicular secretory protein Li 65; vacuolar H+-ATPase 56,000 subunit; vacuolar proton pump subunit B 2; ATP6V1B2蛋白;


背景信息:
Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. The V-ATPase V1 B subunit exists as two isoforms. In the inner ear, the V-ATPase B1 isoform functions in proton secretion and is required to maintain proper endolymph pH and normal auditory function. The gene encoding the human V-ATPase B1 isoform maps to chromosome 2cen-q13. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. The V-ATPase B2 isoform is expressed in kidney and is the only B isoform expressed in osteoclasts. The gene encoding the human V-ATPase B2 isoform maps to chromosome 8p22-p21.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。