SB 206553 HCl is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). It exhibits > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). References: Moller-Acuna P, Contreras-Riquelme JS, Rojas-Fuentes C, Nunez-Vivanco G, Alzate-Morales J, Iturriaga-Vásquez P, Arias HR, Reyes-Parada M. Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile. PLoS One. 2015 Aug 5;10(8):e0134444. doi: 10.1371/journal.pone.0134444. eCollection 2015. PubMed PMID: 26244344; PubMed Central PMCID: PMC4526571.

纯度：≥98%

CAS：1197334-04-5