KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), formerly known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase. KYP-2047 reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. References: Savolainen MH, Richie CT, Harvey BK, Mannisto PT, Maguire-Zeiss KA, Myohanen TT. The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. Neurobiol Dis. 2014 Aug;68:1-15. doi: 10.1016/j.nbd.2014.04.003. PubMed PMID: 24746855.

纯度：≥98%

CAS：796874-99-2