Lingo-3 is a 592 amino acid single-pass type I membrane protein. Lingo-3 contains one immunoglobulin-like C2-type domain and fourteen leucine-rich repeats and is glycosylated at various positions during post-translational modification. Lingo-3 is expressed in a broad but specific pattern in many tissues across the embryo. The gene encoding Lingo-3 maps to to human chromosome 19p13.3 and mouse chromosome 10 C1. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc alpha receptors.