C20orf108 is a 192 amino acid multi-pass membrane protein that contains one DUF1279 domain. C20orf108 is encoded by a gene located on human chromosome 20q13.2. Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought to be important for seminal production. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf108 gene product has been provisionally designated C20orf108 pending further characterization.