GIN1 is a 522 amino acid protein containing one integrase catalytic domain. Widely expressed, GIN1 is also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate. Three isoforms of GIN1 are produced by alternative splicing events. The gene encoding GIN1 maps to human chromsome 5q21.1. Chromosome 5 contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. Treacher Collins syndrome, Cockayne syndrome and familial adenomatous polyposis are also associated with chromosome 5.