| CAS NO: | 2126744-35-0 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
Chemical Properties | Molecular Weight: 316.78 Formula: C17H17ClN2O2 CAS No.: 2126744-35-0 SMILES: O=C(NO)C1=CC=C(CN2CCCC3=C2C=CC(Cl)=C3)C=C1 |
|---|---|
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Technical Information | SW-100; SW 100; SW100 |
| Target | IC50: HDAC1:5.23 μM; HDAC2:32.8 μM; HDAC3:29.5 μM; HDAC4:10.9 μM; HDAC5:4.07 μM; HDAC6:2.3 nM; HDAC7:4.55 μM; HDAC8:3.72 μM; HDAC9:3.46 μM; HDAC10:26.2 μM; HDAC11:5.72 μM |
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| In Vitro | SW-100 (0.01-10 μM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: HEK293 cells Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 48 hours Result: Showed obvious increase in the acetylated α-tubulin levels in a dose-dependent manner. |
| In Vivo | SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1]. Animal Model: 8-10 weeks old C57BL/6 mice (Fmr1-/- mice)[1] Dosage: 20 mg/kg Administration: Intraperitoneal injection; twice a day for two days Result: Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1-/- mice。 |
| References | [1]. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695 |
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