ZNF251 (Zinc Finger Protein 251) is located on human chromosome 8q24.3. ZNF251 is associated with some diseases, such as Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Herpes simplex virus 1 infection. ZNF251 gene is related to nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF568. ZNF251 may be involved in transcriptional regulation. ZNF251, which belongs to the zinc finger protein family, is one of the somatic genes that is mutated in pulmonary sclerosing pneumocytoma, which presents with diffusely scattered nodules in the right lung. ZNF251plays oncogenic roles in lung cancer by activating ERK signaling and ZNF251 is a promising therapeutic target for lung cancer treatment.