NOXRED1 (NADP Dependent Oxidoreductase Domain Containing 1) is located on human chromosome 14q24.3. The NOXRED1 protein is broadly expressed in testis, thyroid and other tissues. Structurally, the encoded protein is reported to be 39880 Da in mass. The NOXRED1 (also known as C14orf148) gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 220 organisms have orthologs with human gene NOXRED1. NOXRED1 is associated with Visual Cortex Disease and Visual Pathway Disease. NOXRED1 is related to pyrroline-5-carboxylate reductase activity. An important paralog of this gene is PYCR1.