RPR260243 is a novel activator of HERG. It modifies HERG currents inhibited by dofetilide (IC50 = 58 nM). RPR260243 has little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. References: Gardner A, Sanguinetti MC. C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation. Mol Pharmacol. 2015 Jul;88(1):19-28. doi: 10.1124/mol.115.098384. Epub 2015 Apr 17. PubMed PMID: 25888115; PubMed Central PMCID: PMC4468633.

纯度：≥98%

CAS：668463-35-2