您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Lecozotan HCl
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lecozotan HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:433282-68-9
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Lecozotan, formerly known as SRA-333, is a potent and selective 5-HT antagonist potentially for the treatment of Alzheimer's disease. Lecozotan (SRA-333) enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. Chronic administration of lecozotan did not induce 5-HT(1A) receptor tolerance or desensitization in a behaviorally bioavailable model indicative of 5-HT(1A) receptor function. Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behaviorally bioavailable depression. References: Parks V, Philipp AW, Raje S, Plotka A, Schechter LE, Connell J, Chalon S. Concomitant blockade of 5-HT(1A) receptor and 5-HT transporter: use of the Hunter Serotonin toxicity criteria in a clinical pharmacology study. Eur Neuropsychopharmacol. 2012 Feb;22(2):92-9. doi: 10.1016/j.euroneuro.2011.06.002. PubMed PMID: 21733663.

纯度:≥98%

CAS:433282-68-9