Ro67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 is 7.16 for the rat mGlu1a receptor). Ro67-4853 exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. It enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM). References:

纯度：≥98%

CAS：302841-89-0