Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Kis are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 exhibits partial agonism at DI α4- and α6-GABAA receptors. References: Contó MB, Hipólide DC, de Carvalho JG, Venditti MA. Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding. Epilepsy Res. 2012 Feb;98(2-3):216-22. doi: 10.1016/j.eplepsyres.2011.09.014. PubMed PMID: 22005005.

纯度：≥98%

CAS：91917-65-6