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2F-Peracetyl-Fucose
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2F-Peracetyl-Fucose图片
规格:98%
分子量:292.3
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍
2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) 是一种有效的岩藻糖基转移酶 (FUT) 抑制剂。
货号:ajcx21270
CAS:188783-78-0
分子式:C12H17FO7
分子量:292.3
溶解度:Chloroform: soluble,Methanol: soluble,DMSO: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

2F-Peracetyl-fucose is an inhibitor of protein fucosylation.[1] It inhibits fucosylation of IgG1 monoclonal antibodies produced by CHO-DG44 cells when used at a concentration of 50 &#181M. It reduces intracellular GDP-fucose levels in CHO-DG44 cells in a concentration-dependent manner. 2F-Peracetyl-fucose (100 &#181M) also decreases intracellular fucose levels in A. thaliana seedlings.[2] 2F-Peracetyl-fucose decreases root length in A. thaliana seedlings in a concentration-dependent manner.

参考文献:
[1].Okeley, N.M., Alley, S.C., Anderson, M.E., et al.Development of orally active inhibitors of protein and cellular fucosylationProc. Natl. Acad. Sci. USA110(14)5404-5409(2013)
[2].Villalobos, J.A., Yi, B.R., and Wallace, I.S.2-Fluoro-L-fucose is a metabolically incorporated inhibitor of plant cell wall polysaccharide fucosylationPLoS One10(9)e0139091(2015)