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Dexamethasone-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dexamethasone-d4图片
规格:98%
分子量:396.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22256
CAS:2483831-63-4
分子式:C22H25D4FO5
分子量:396.5
溶解度:DMF: 25 mg/ml,DMSO: 30 mg/ml,Ethanol: 3 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dexamethasone-d4is intended for use as an internal standard for the quantification of dexamethasone by GC- or LC-MS. Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd= 5 nMversus17 nM, respectively).1Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.2


1.Mulatero, P., Panarelli, M., Schiavone, D., et al.Impaired cortisol binding to glucocorticoid receptors in hypertensive patientsHypertension30(5)1274-1278(1997) 2.Beck, I.M., Vanden Berghe, W., Vermeulen, L., et al.Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatasesEndocr. Rev.30(7)830-882(2009)