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K-41
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K-41图片
包装:1mg
规格:98%
市场价:2769元
分子量:947.2

产品介绍
A fungal metabolite with antibiotic and antiparasitic activities
货号:ajcx22760
CAS:53026-37-2
分子式:C48H82O18
分子量:947.2
溶解度:Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

K-41 is a monoglycoside polyether fungal metabolite originally isolated fromS. hygroscopicusthat has antibiotic and antiparasitic activities.1,2It is active againstB. subtilis,B. anthracis,S. aureus,S. pyogenes,S. pneumoniae,C. diphtheriae, andM. tuberculosis(MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively).1K-41 is active against the K1 drug-resistant and FCR3 drug-susceptibleP. falciparumstrains (IC50s = 8.5 and 31 nM, respectively).2In vivo, K-41 has antiparasitic activity in mouse models ofP. bergheiandP. yoeliiinfection (ED50s = 1.9 and 7.0 mg/kg, respectively).


1.Tsuji, N., Nagashima, K., Kobayashi, M., et al.Two new antibiotics, A-218 and K-41. Isolation and characterizationJ. Antibiot. (Tokyo)29(1)10-14(1976) 2.Moreno, M., and Giralt, E.Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparanToxins71126-1150(2015)