A STING agonist
货号:ajcx23534
CAS:652142-94-4
分子式:C19H11Cl2N5O
分子量：396.2
溶解度:DMF: slightly soluble,DMSO: slightly soluble,PBS (pH 7.2): slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

STING agonist 1a is an agonist of stimulator of interferon genes (STING).¹It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC₅₀= 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)