3-hydroxycoumarin 是人类 15-LOX-1 的有效氧化还原抑制剂。
货号:ajcx25684
CAS:939-19-5
分子式:C9H6O3
分子量：162.1
溶解度:DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3-Hydroxycoumarin is a coumarin that has been found inA. reinwardtiiand has diverse biological activities.^1,2,3It inhibits 15-lipoxygenase-1 (15-LO-1; IC₅₀= 9.5 µM).¹3-hydroxycoumarin scavenges DPPH radicals in a cell-free assay (IC₅₀= 0.61 mM) and inhibits lipid peroxidationin vitro(IC₅₀= 69.07 mM).²It is protective against UVB-induced embryotoxicity in sea urchins (E. lucunter).³

1.Alavi, S.J., Sadeghian, H., Seyedi, S.M., et al.A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarinChem. Biol. Drug Des.91(6)1125-1132(2017) 2.Rattanapan, J., Sichaem, J., and Tip-pyang, S.Chemical constituents and antioxidant activity from the stems of Alyxia reinwardtiiRec. Nat. Prod.6(3)288-291(2012) 3.de Araujo Leite, J.C., de Castro, T.M.X., Barbosa-Filho, J.M., et al.Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cellsJ. Photochem. Photobiol. B Biol.14644-51(2015)