您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > 3-Hydroxycoumarin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
3-Hydroxycoumarin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-Hydroxycoumarin图片
包装:5g
规格:98%
市场价:3244元
分子量:162.1

产品介绍
3-hydroxycoumarin 是人类 15-LOX-1 的有效氧化还原抑制剂。
货号:ajcx25684
CAS:939-19-5
分子式:C9H6O3
分子量:162.1
溶解度:DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

3-Hydroxycoumarin is a coumarin that has been found inA. reinwardtiiand has diverse biological activities.1,2,3It inhibits 15-lipoxygenase-1 (15-LO-1; IC50= 9.5 µM).13-hydroxycoumarin scavenges DPPH radicals in a cell-free assay (IC50= 0.61 mM) and inhibits lipid peroxidationin vitro(IC50= 69.07 mM).2It is protective against UVB-induced embryotoxicity in sea urchins (E. lucunter).3


1.Alavi, S.J., Sadeghian, H., Seyedi, S.M., et al.A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarinChem. Biol. Drug Des.91(6)1125-1132(2017) 2.Rattanapan, J., Sichaem, J., and Tip-pyang, S.Chemical constituents and antioxidant activity from the stems of Alyxia reinwardtiiRec. Nat. Prod.6(3)288-291(2012) 3.de Araujo Leite, J.C., de Castro, T.M.X., Barbosa-Filho, J.M., et al.Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cellsJ. Photochem. Photobiol. B Biol.14644-51(2015)