规格: | 98% |
分子量: | 373.4 |
包装 | 价格(元) |
5mg | 电议 |
25mg | 电议 |
Background:
AZD 2716 is an inhibitor of secretory phospholipase A2(sPLA2; IC50s = 0.01, 0.04, and 0.4 µM for sPLA2-IIa, -V, and -X, respectively).1It inhibits sPLA2activity in atherosclerotic plaque homogenates isolated from patients with coronary artery disease (IC50= 56 nM).
1.Giordanetto, F., Pettersen, D., Starke, I., et al.Discovery of AZD2716: A novel secreted phospholipase A2 (sPLA2) inhibitor for the treatment of coronary artery diseaseACS Med. Chem. Lett.7(10)884-889(2016)