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CHR 6494 trifluoroacetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CHR 6494 trifluoroacetate图片
包装:10mg
规格:98%
市场价:2430元
分子量:406.36

产品介绍
Potent and selective haspin inhibitor
货号:ajcx27008
CAS:1458630-17-5
分子式:C16H16N6.CF3CO2H
分子量:406.36
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.


Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID:21804608