ML 382 是一种有效且选择性的 MRGPRX1（Mas 相关 G 蛋白偶联受体 X1，MrgX1）正变构调节剂，EC50 为 190 nM。
货号:ajcx27206
CAS:1646499-97-9
分子式:C18H20N2O4S
分子量：360.43
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.

Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID:25209672