PDD 00017238 是一种有效的 Poly(ADP-ribose) Glycohydrolase (PARG) 抑制剂，在生化试验和细胞 POM 中的 EC50 值分别为 40 nM 和 55 nM。
货号:ajcx27950
CAS:1952247-05-0
分子式:C19H20N6O3S3
分子量：476.59
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity and potent PARG inhibitor (Kd = 3.09 nM; IC50 = 40 nM). Negative control PDD 00031705 also available.

James et al (2016) First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 11 3179 PMID:27689388