An inhibitor of NF-κB
货号:ajcx28560
CAS:791595-09-0
分子式:C17H27NO3
分子量：293.4
溶解度:DMF: Miscible,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: Miscible,Ethanol: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dimethylamino parthenolide (DMAPT) is an inhibitor of NF-κB and a derivative of parthenolide .¹It inhibits the binding of the p65 subunit of NF-κB to DNA by 75% when used at a concentration of 50 µM. DMAPT (25 µM) decreases intracellular glutathione (GSH) levels in, and inhibits the migration of, MDA-MB-231 breast cancer cells. It induces necrosis in MDA-MB-231 cells, an effect that can be reversed by the antioxidant N-acetyl cysteine , NADPH oxidase inhibitor apocynin , or RIP1 kinase inhibitor necrostatin-1 . DMAPT (50 mg/kg) decreases tumor volume in an MDA-MB-231 mouse xenograft model.

1.D'Anneo, A., Carlisi, D., Lauricella, M., et al.Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancerCell Death Dis.4(e891)(2013)