AAK1-IN-1 (example 123) 是一种 AAK1 (adaptor associated kinase 1) 抑制剂，IC50 为 2.2 nM。AAK1-IN-1 可用于神经退行性疾病的研究。
货号:ajcx34480
CAS:1815613-42-3
分子式:C19H23F4N3O
分子量：385.4
溶解度:DMSO : 220 mg/mL (570.84 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1].

Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis[1].

[1]. Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.