Desmethyl cariprazine 是 Cariprazine 的活性代谢产物。Cariprazine，是抗精神病药候选药物，结合 D3, D2 和 5-HT1A 的 Ki 为 0.085 nM，0.49 nM，2.6 nM。
货号:ajcx34680
CAS:839712-15-1
分子式:C20H30Cl2N4O
分子量：413.38
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Desmethyl cariprazine is an active metabolite of Cariprazine[1]. Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM)[2].

[1]. Campbell RH, et al. Review of cariprazine in management of psychiatric illness. Ment Health Clin. 2018 Mar 23;7(5):221-229.
[2]. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8.