Cycleanine 是一种高效的血管选择性 Ca- 拮抗剂。Cycleanine 具有缓解疼痛、肌肉松弛和抗炎作用。Cycleanine 具有通过凋亡通路发挥抗卵巢癌作用的潜力。
货号:ajcx36712
CAS:518-94-5
分子式:C38H42N2O6
分子量：622.75
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

[1]. MartÍnez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12(2):182-7.
[2]. Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9.