GSK329 是一种有效和选择性的心脏特异性激酶 TNNI3K 的二芳基脲抑制剂。 GSK329 在缺血/再灌注心脏损伤模型中表现出积极的心脏保护结果。
货号:ajcx37914
CAS:1268490-12-5
分子式:C19H14Cl2F3N5O2
分子量：472.25
溶解度:DMSO : 250 mg/mL (529.38 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK329 is a potent and selective diarylurea inhibitor of the cardiac-specific kinase TNNI3K. GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury[1].

[1]. Patterson JR, et, al. Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf. J Med Chem. 2021 Nov 11;64(21):15651-15670.