Sappanchalcone 从 Caesalpinia sappan L. 中提取的黄酮类化合物，诱导人结肠癌细胞凋亡 (apoptosis)。
货号:ajcx38016
CAS:94344-54-4
分子式:C16H14O5
分子量：286.28
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].

[1]. Seo HW, et al. Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells. Chem Biol Interact. 2020;327:109185.