AZD-7648 是一种具有选择性的口服有效 DNA-PK 抑制剂，IC50 值为 0.6 nM, AZD-7648 诱导细胞凋亡 (apoptosis)，具有抗肿瘤活性。
货号:ajcx38594
CAS:2230820-11-6
分子式:C18H20N8O2
分子量：380.4
溶解度:DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1].

AZD7648 (0-30 μM) is a potent radiosensitizer[1].AZD7648 (3 μM) increases sensitivity to doxorubicin[1].AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib[1].

AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression[1].

[1]. Fok JHL, et al. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065.