CDC25B-IN-1 (compound 4a) 是一种有效的细胞分裂周期 25B (CDC25B) 磷酸酶抑制剂，其 Ki 值为 8.5 μM。CDC25B-IN-1 能有效抑制细胞增殖和克隆形成，导致 G2/M 期停滞。
货号:ajcx13788
CAS:N/A
分子式:C20H19NO3
分子量：321.37
溶解度:DMSO: 100 mg/mL (311.17 mM); Ethanol: 50 mg/mL (155.58 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase[1]. Ki: 8.5 μM (CDC25B phosphatase)[1]

[1]. Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem. 2019 Aug 8;62(15):7089-7110.