Foxy-5 是一种缺乏硫酸肝素结合域 WNT5A 模拟肽，具有抗转移作用。Foxy-5 在不影响 β-连环蛋白激活的情况下触发细胞溶质游离钙信号传导，并损害上皮癌细胞的迁移和侵袭。
货号:ajcx13908
CAS:N/A
分子式:C28H43F3N6O14S2
分子量：808.8
溶解度:H2O: 20 mg/mL (24.73 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Foxy-5 is a WNT5A mimicking peptide with anti-metastatic effect, which lacks a heparan sulfate-binding domain. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells[1][2][3].

[1]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. [2]. SÄfholm A, et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res. 2008 Oct 15;14(20):6556-63. [3]. Kelsey R. Prostate cancer: Foxy-5 in prostate cancer model. Nat Rev Urol. 2017 Nov;14(11):638.