Synucleozid (NSC 377363) 是可编码 α-突触核蛋白的 SNCA mRNA 的有效抑制剂 (IC50=1.5 μM)。Synucleozid 选择性靶向 α-synuclein mRNA 的 5'UTR的 IRE 位点，减少了加载到多核糖体中的 SNCA mRNA 的量，从而抑制了α-synuclein 蛋白的翻译。Synucleozid 有潜力用于帕金森病的相关研究。
货号:ajcx16764
CAS:N/A
分子式:C22H21ClN6
分子量：404.9
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein (IC50=1.5 μM). Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease[1].

[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.