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Trihydroxycholestanoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trihydroxycholestanoic Acid图片
规格:98%
分子量:450.7
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
A cholic acid intermediate
货号:ajcx20260
CAS:547-98-8
分子式:C27H46O5
分子量:450.7
溶解度:Chloroform: slightly, heated, DMSO: slightly soluble, Ethanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.2,3


|1. Keane, M.H., Overmars, H., Wikander, T.M., et al. Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice. Hepatology 45(4), 982-997 (2007).|2. Ferdinandusse, S., Overmars, H., Denis, S., et al. Plasma analysis of di- and trihydroxycholestanoic acid diastereoisomers in peroxisomal α-methylacyl-CoA racemase deficiency. J. Lipid Res. 42(1), 137-141 (2001).|3. Klouwer, F.C.C., Berendse, K., Ferdinandusse, S., et al. Zellweger spectrum disorders: Clinical overview and management approach. Orphanet J. Rare Dis. 10, 151 (2015).