Ani 9 是一种有效的选择性跨膜蛋白 16A (TMEM16A, Anoctamin-1) 阻断剂，IC50 为 77 nM。
货号:ajcx20520
CAS:356102-14-2
分子式:C17H17ClN2O3
分子量：332.8
溶解度:25mg/mL in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM).[1] It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.

参考文献:
[1]. Seo, Y., Lee, H.K., Park, J., et al. Ani9, A novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11(5), e0155771 (2016).