An internal standard for the quantification of (–)-ropivacaine
货号:ajcx20814
CAS:1217667-10-1
分子式:C17H19D7N2O.HCl
分子量：317.9
溶解度:Methanol: soluble,Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(-)-Ropivacaine-d₇is intended for use as an internal standard for the quantification of (-)-ropivacaine by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers.¹In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve.²(-)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (-)- and (±)-bupivacaine .³Formulations containing (-)-ropivacaine have been used as local anesthetics during surgery and childbirth.

1.Hansen, T.G.Ropivacaine: A pharmacological reviewExp. Rev. Neurother.4(5)781-791(2004) 2.Sinnott, C.J., and Strichartz, G.R.Levobupivacaine versus ropivacaine for sciatic nerve block in the ratReg. Anesth. Pain Med.28(4)294-303(2003) 3.Pinotti, M.F., Hepner, A., Campos, D.H., et al.Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative studyActa Cir. Bras.30(7)484-490(2015)