A neuropeptide with diverse biological activities
货号:ajcx20884
CAS:N/A
分子式:C16H11D4F6N5O.HCl
分子量：447.8
溶解度:Water: Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(±)-Sitagliptin-d₄is intended for use as an internal standard for the quantification of sitagliptin by GC- or LC-MS. Sitagliptin is a mixture of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin and (+)-sitagliptin, also known as sitagliptin impurity E, a potential impurity found in commercial preparations of (-)-sitagliptin.¹(-)-Sitagliptin is a potent inhibitor of DPP-4 (IC₅₀= 18 nM).²It is selective for DPP-4 over DPP-8 (IC₅₀= 48 µM) as well as several other peptidases, including DPP-9, DPP-2, and amino peptidase P.^2,3(-)-Sitagliptin improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well asob/oband high-fat diet fed mice.⁴It also reduces hyperglycemia in mice fed a high-fat diet with diabetes induced by streptozotocin . Formulations containing (-)-sitagliptin have been used in the treatment of type 2 diabetes mellitus.

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