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Adenosine 5'-diphosphate(potassium salt hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adenosine 5'-diphosphate(potassium salt hydrate)图片
规格:98%
分子量:466.3
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21622
CAS:N/A
分子式:C10H15N5O10P2.K [XH2O]
分子量:466.3
溶解度:PBS (pH 7.2): 10 mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Adenosine 5'-diphosphate (ADP) is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5' position. It is produced by dephosphorylation of adenosine 5'-triphosphate by ATPases and can be converted back to ATP by ATP synthases. ADP can also be metabolized to adenosine 5'-monophosphate and 2'-deoxyadenosine 5'-diphosphate (dADP). ADP can modulate several receptors, activating certain purinergic receptors (EC50= 24 nM for P2Y1) and inhibiting others (IC50= 67 nM for P2X2/3), inhibiting rat ecto-5'nucleotidase (Ki= 0.91 nM), and regulating the phosphorylation status of AMP-activated protein kinase (AMPK).1,2,3,4


1.Azran, S., FÖrster, D., Danino, O., et al.Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonistsJ. Med. Chem.56(12)4938-4952(2013) 2.Baqi, Y., Lee, S.-Y., Iqbal, J., et al.Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffoldJ. Med. Chem.53(5)2076-2086(2010) 3.Jarvis, M.F., Bianchi, B., Uchic, J.T., et al.[3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptorsJournal of Pharmacology and Experimental Therapeutics310(1)407-416(2004) 4.Ruderman, N.B., Carling, D., Prentki, M., et al.AMPK, insulin resistance, and the metabolic syndromeJ. Clin. Invest.123(7)2764-2772(2013)