An inhibitor of CYP4Z1
货号:ajcx22042
CAS:2428734-45-4
分子式:C14H20N4O2
分子量：276.3
溶解度:Chloroform: 10 mg/ml,Ethanol: 1 mg/ml,Methyl Acetate: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC₅₀= 5.9 µM).¹It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC₅₀s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC₅₀s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.

1.Kowalski, J.P., McDonald, M.G., Pelletier, R.D., et al.Design and characterization of the first selective and potent mechanism-based inhibitor of cytochrome P450 4Z1J. Med. Chem.63(9)4824-4836(2020)