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Evodiamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Evodiamine图片
CAS NO:518-17-2
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)303.36
FormulaC19H17N3O
CAS No.518-17-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)

Chemical Name: (S)-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

InChi Key: TXDUTHBFYKGSAH-SFHVURJKSA-N

InChi Code: InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1

SMILES Code: O=C1N2[C@](C(NC3=C4C=CC=C3)=C4CC2)([H])N(C)C5=C1C=CC=C5

SynonymsIsoevodiamine; (+)-Evodiamine; d-Evodiamine; Q-100579; SC-16015; Q100579; SC16015; Q 100579; SC 16015
实验参考方法
In Vitro

In vitro activity: Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. In addition, Evodiamine is an human topoisomerase I inhibitor.


Kinase Assay: Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin (sc-3577, Ki = 1.8 microM).


Cell Assay: Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine (sc-201098). Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects. The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine.

In Vivo
Animal model
Formulation & Dosage
References

Mol Cancer Ther. 2006 Sep;5(9):2398-407; J Biol Chem. 2005 Apr 29;280(17):17203-12.