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Sumatriptan-d6(succinate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sumatriptan-d6(succinate)图片
包装:1mg
规格:98%
市场价:1603元
分子量:360.4

产品介绍
An internal standard for the quantification of sumatriptan
货号:ajcx23540
CAS:1397195-80-0
分子式:C14H15D6N3O2S.1/2C4H6O4
分子量:360.4
溶解度:DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Sumatriptan-d6is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1Band 5-HT1D(IC50s = 9.3 and 7.3 nM, respectively).1It also binds to the 5-HT1Freceptor (IC50= 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50= 89.9 nM), an effect that can be reduced by the 5-HT1B/1Dreceptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2Formulations containing sumatriptan have been used in the treatment of migraine headache.


1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)