| 规格: | 98% |
| 分子量: | 380.4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
INNO-8875 is an adenosine A1receptor agonist.1,2It binds to adenosine A1receptors (Ki= 0.97 nM) and is greater than 10,000-fold selective for adenosine A1over A2receptors. Topical application of INNO-8875 (25 µg/eye) reduces intraocular pressure in a rabbit model of ocular hypertension.2INNO-8875 (1-50 µg/kg) decreases atrial refractoriness and heart rate, as well as slows atrioventricular nodal conduction, in anesthetized rats.1
1.Mor, M., Shalev, A., Dror, S., et al.INO-8875, a highly selective A1 adenosine receptor agonist: Evaluation of chronotropic, dromotropic, and hemodynamic effects in ratsJ. Pharmacol. Exp. Ther.344(1)59-67(2012) 2.Kim, N., Crosson, C., Supuran, C., et al.INO-8875, an adenosine A1 agonist, in development for open-angle glaucoma reduces IOP in three rabbit modelsInvert. Ophthalmol. Vis. Sci.50(13)4061(2009)
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