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ITH15004
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ITH15004图片
规格:98%
分子量:341.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A P2X7 receptor antagonist
货号:ajcx24496
CAS:N/A
分子式:C13H7Cl3N4O
分子量:341.6
溶解度:DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 µM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 µM. ITH15004 (1 µM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA).


1.Calzaferri, F., Narros-FernÁndez, P., de Pascual, R., et al.Synthesis and pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammationJ. Med. Chem.64(4)2272-2290(2021)