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N-desmethyl Olanzapine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Olanzapine图片
规格:98%
分子量:298.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A major metabolite of olanzapine
货号:ajcx24640
CAS:161696-76-0
分子式:C16H18N4S
分子量:298.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine .1,2N-desmethyl Olanzapine is formedviaoxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.1


1.Ring, B.J., Catlow, J., Lindsay, T.J., et al.Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapineJ. Pharmacol. Exp. Ther.276(2)658-666(1996) 2.Chiu, J.A., and Franklin, R.B.Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detectionJ. Pharm. Biomed. Anal.14(5)609-615(1996)