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IQ 1S
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IQ 1S图片
规格:98%
分子量:269.23
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
JNK inhibitor; anti-inflammatory; also NO donor
货号:ajcx27126
CAS:1421610-21-0
分子式:C15H8N3NaO
分子量:269.23
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.


Schepetkin et al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505 PMID:25784649 |Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID:22434859 |Atochin et al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45 PMID:26923672