Desglymidodrine (ST 1059) 是 Midodrine 的活性代谢物，是一种选择性 α1-肾上腺素受体激动剂。
货号:ajcx28288
CAS:3600-87-1
分子式:C10H15NO3
分子量：197.2
溶解度:DMF: 1 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Desglymidodrine is the active metabolite of the prodrug midodrine .¹It is formed from midodrine by enzymatic hydrolysis.²Desglymidodrine is an agonist of α₁-adrenergic receptors (α₁-ARs).¹It binds to α₁-ARs (K_is = 9.77, 9.55, and 8.51 µM for α_1A, α_1B, and α_1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.

1.Altenbach, R.J., Khilevich, A., Kolasa, T., et al.Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing α1A-adrenoceptor agonistJ. Med. Chem.47(12)3220-3235(2004) 2.McClellan, K.J., Wiseman, L.R., and Wilde, M.I.Midodrine. A review of its therapeutic use in the management of orthostatic hypotensionDrugs Aging12(1)76-86(1998)