| 规格: | 98% |
| 分子量: | 874.3 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
Background:
TCL053 is an ionizable amino lipid.1It has been used in the generation of lipid nanoparticles (LNPs) and has a pKavalue of 6.8. LNPs containing TCL053 and encapsulating mRNA encoding the Cas9 nuclease, in combination with LNPs containing TCL053 and encapsulating single-guide RNA (sgRNA) targeting the Rosa26 locus, have been used to induce CRISPR-mediated gene editing in the mouse gastrocnemius muscle.
1.Kenjo, E., Hozumi, H., Makita, Y., et al.Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in miceNat. Commun.12(1)7101(2021)
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